Lisman Labs Bioinformatics

In my research at Lisman Laboratories, I analyzed data from the Allen Institute, which included morphological, electrophysiological, and transcriptomic information for 573 GABAergic interneurons from the mouse visual cortex. On Google Colab, I identified genes correlated with specific neuron morphologies. Notably, I found that the gene Grik1 was significantly upregulated in neurons with a high axon surface area to volume ratio. This gene, along with others like Rbfox1 and Fmn1, showed strong correlations with axonal and dendritic features. These genes fit into distinct functional categories, such as RNA binding and actin regulation, highlighting their roles in neural development. This unique approach of integrating transcriptomic data with detailed neuronal morphology helps refine our understanding of the genetic basis of neural structure.

Check out the slides presentation here: